Acta Pharm. 55 (2005) 287-296

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Original research paper 
 

Synthesis of some oxazolinones and imidazolinones and their antimicrobial screening

BIPLAB DE1, JAYANTA KUMAR GUPTA2 and  VENKATAPURAM SAMPATH SARAVANAN2

biplab_32@yahoo.co.in

1Regional Institute of Pharmaceutical Science & Technology, Abhoynagar, Agartala, Tripura-799005, India
2Department of Pharmaceutical Technology, Jadavpur University, Jadavpur, Kolkata, West Bengal. Pin-700032, India
Received August 27, 2004      Accepted May 24, 2005

A few imidazolinones [1-aminoethyl/phenyl-2-methyl/phenyl-4-acetylidene/benzylidene-imidazolin-5(4H)-ones] were newly synthesized from respetive acetylidene/benzylidene oxazolinones. Schiff's bases were synthesized by the reaction between imidazolinones and benzaldehyde. The antimicrobial screening of almost all compounds showed moderate to significant activities against B. subtilis ATCC 6633 and K. pneumoniae ATCC 25063. Compounds 10 [1-aminophenyl-2-phenyl-4-acetylidene-imidazolin-5(4H)-one] and 12 [1-aminophenyl-2-phenyl-4-benzylidene-imidazolin-5(4H)-one] showed even better activity than amphotericin B against C. albicans ATCC 29738.


Keywords: imidazolin-5(4H)-ones, oxazolinones, Schiff's bases, antimicrobial activity