Acta Pharm. 68 (2018) 295-311
Original research paper
Comparative evaluation
of the use of dry binders in a physical mixture or as a coprocessed
dry binder in matrix tablets with extended
drug release
JITKA MUŽÍKOVÁ, ALENA KOMERSOVÁ, VÁCLAV LOCHAŘ, LUCIE VILDOVÁ, BÁRA
VOŠOUSTOVÁ and MARTIN BARTOŠ
Department of
Pharmaceutical Technology, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic
2 Department of Physical Chemistry, Faculty of
Chemical Technology, University
of Pardubice, Czech
Republic
3 Department of Analytical Chemistry, Faculty of
Chemical Technology, University
of Pardubice, Czech
Republic
Accepted April 5, 2018
Published online April 20,
2018
This paper evaluates and
compares the properties of directly compressible tabletting
materials and matrix tablets containing a combination of α-lactose
monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical
mixture and in a coprocessed dry binder. Tested
parameters include flow properties, compressibility, compactibility
and the rate of drug release from tablets. Compressibility is evaluated by
means of the energy profile of the compression process. Compactibility
is evaluated by means of the tensile strength of the tablets. Dissolution
testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis. Total energy of compression and
plasticity values were higher in tabletting materials
with the coprocessed dry binder. Increasing additions
of polyvinyl alcohol decreased the values of total energy of compression,
plasticity, tensile strength of tablets and drug release
rate. Dissolution
behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl
alcohol, was
comparable.
Keywords: coprocessed
dry binder, matrix tablets, polyvinyl alcohol, energy profile of compression,
tensile strength of tablets, dissolution testing