Acta Pharm. 66 (2016) 297-302

 

full paper

Short communication

 

Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes

DONG-GI LEE, IK SOON JANG, KYEONG EUN YANG, SO-JUNG YOON, SUJEONG BAEK, JOO YONG LEE, TATSURO SUZUKI, KEUN-YOOK CHUNG, SUN-HEE WOO and JONG-SOON CHOI

shwoo@chungbuk.ac.kr, jschoi@kbsi.re.kr

1 Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea

2 Drug & Disease Target Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea

3 Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea

4 National Agricultural Research Center for Hokkaido Region, Memuro, Hokkaido 0820081, Japan

5 Department of Agricultural Chemistry, Chungbuk National University, Cheongju 28644, Republic of Korea

6 Department of Crop Science, Chungbuk National University, Cheongju 28644, Republic of Korea

Accepted January 11, 2016

Published online April 8, 2016

 

This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.

 

Keywords: tartary buckwheat sprout, rutin, type 2 diabetes, insulin signaling