Acta Pharm. 59 (2009) 313-323

 

full paper

Original research paper

 

Effects of drug solubility on the release kinetics of water soluble and insoluble drug from HPMC based matrix formulations

 

SANTANU CHAKRABORTY, MADHUSMRUTI KHANDAI, ANURADHA SHARMA, C. NIRANJAN PATRA, V. JAGANNATH PATRO and KALYAN KUMAR SEN

santanu_nil@rediffmail.com

1 P.G. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002, Orissa, India

2 P.G. Department of Pharmaceutics, Gupta College of Pharmaceutical Sciences, Asansol, West Bengal, India

Accepted July 8, 2009

 

The purpose of the present research work was to observe the effects of drug solubility on the release kinetics of water soluble verapamil hydrochloride and insoluble aceclofenac from polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of tablets were studied. Applying an exponential equation, it was found that the kinetics of soluble drug release followed anomalous non-Fickian diffusion transport whereas insoluble drug showed zero-order release. SEM study showed pore formation on the tablet surface that differed depending on drug solubility. t-Test pointed to a significant difference in the amount of both drugs released due to their difference in solubility. Solubility of the drug affects the kinetics and the mechanism of drug release.

 

Keywords: solubility, release kinetics, swelling, erosion, matrix tablets, statistical analysis