Acta Pharm. 58 (2008) 317-326

full paper

Short communication

2-Amino-5-sulfanyl-1,3,4-thidiazoles: A new series of selective cyclooxygenase-2 inhibitors

RAJESH SHARMA, JITENDRA SAINY and SUBHASH CHANDRA CHATURVEDI

rbsm73@yahoo.co.in

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshsila Campus, Khandwa Road, Indore, Madhya Pradesh-452 017, India

Accepted May 12, 2008

A new series of cyclooxygenase-2 inhibitors with 2-amino-5-sulfanyl-1,3,4-thiadiazole as the central scaffold unit has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for cyclooxygenase inhibitory activity by colorimetric COX (ovine) inhibitor screening assay, anti-inflammatory activity by the carrageenean induced rat paw oedema test and analgesic activity by the tail flick method. Some compounds exhibited significant biological activity.

Keywords: 2-amino-5-sulfanyl-1,3,4-thiadiazoles, cyclooxygenase-1, cyclooxygenase-2, anti-inflammatory activity, analgesic activity