Acta Pharm. 61 (2011) 335-342

 

full paper

Short communication

 

Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum

SONIAMOL JOSEPH, BABY SABULAL, VARUGHESE GEORGE, KUTTIKKADAN RONY ANTONY and KAINOOR KRISHNANKUTTY JANARDHANAN

sabulal@gmail.com

1 Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram-695562, India

2 Amala Cancer Research Centre, Amala Nagar, Thrissur-680555, India

3 Amity Institute for Herbal and Biotech Products Development, Peroorkada, Thiruvananthapuram-695005, India

Accepted July 15, 2011

 

In this study, polysaccharides were isolated from Ganoderma lucidum (Polyporaceae) and their antitumor and anti-inflammatory activities were investigated using in vivo models. Potential antitumor activity was shown by G. lucidum polysaccharides (GLP) against solid tumor induced by Ehrlich’s ascites carcinoma cells. GLP at 100 mg kg–1 body mass showed 80.8 and 77.6 % reduction in tumour volume and tumour mass, respectively, when administered 24 h after tumour implantation. Again, GLP at the same dose but when administered prior to tumour inoculation, showed 79.5 and 81.2 % inhibition of tumour volume and tumour mass, respectively. GLP showed significant dose-dependent activity in carrageenean-induced (acute) and formalin-induced (chronic) inflammation assays. At 100 mg kg–1, GLP exhibited 57.6 and 58.2 % inhibition in carrageenean-induced and formalin-induced assays, respectively.

 

Keywords: Ganoderma lucidum (Polyporaceae), polysaccharides, anti-inflammatory activity, antitumor activity