Acta Pharm. 60 (2010) 339-348

full paper

Original research paper

Evaluation of binding properties of Plantago psyllium seed mucilage

Majid Saeedi, Katayoun Morteza-Semnani, Farshad Ansoroudi, Saeed Fallah and Gholamreza Amin

majsaeedi @ yahoo.com

¹Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

²Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran

³Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

⁴Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Accepted July 28, 2010

Mucilage extracted from Plantago psyllium seeds was evaluated for inertness and safety parameters. The suitability of psyllium mucilage for a pharmaceutical binder was assessed in paracetamol tablets. Properties of the granules prepared using different concentrations of psyllium mucilage was compared with PVP and tragacanth. Psyllium mucilage at 5 % (m⁄m) level was found to be comparable with 3 % (m⁄m) of PVP. Investigated paracetamol tablets indicated that psyllium mucilage can retard the drug release.

Keywords: Plantago psyllium, mucilage, paracetamol, binder, release