Acta Pharm. 59 (2009) 345-354
Floating drug delivery of a locally acting H2-antagonist: An approach using an in situ gelling liquid formulation
GANAPATI ROHITH, BHIMAGONI KESHAVAMURTHY SRIDHAR and ANEGUNDHA SRINATHA
Department of Pharmaceutics, National College of Pharmacy, Shimoga 577201, India
Accepted June 24, 2009
In the present work, a gastroretentive in situ gelling liquid formulation for controlled delivery of ranitidine was formulated using sodium alginate (low, medium and high viscosity grades), calcium carbonate (source of cations) and ranitidine. Prepared formulations were evaluated for viscosity, buoyancy lag time and buoyancy duration, drug content and in vitro drug release. Formulation variables such as concentration of sodium alginate, calcium carbonate and drug significantly affected the formulation viscosity, floating behavior and in vitro drug release. Analysis of the release pattern showed that the drug release from in situ gel a followed diffusion mechanism.
Keywords: gastroretention, in situ gelling, sodium alginate, ranitidine