Acta Pharm. 57 (2007) 351-359
10.2478/v10007-007-0028-2
Short communication
Preparation and characterization of etoricoxib b-cyclodextrin
complexes prepared by the kneading method
HARESH M. PATEL*,
BHANUBHAI N. SUHAGIA, SHAILESH A. SHAH, ISHWAR SINH RATHOD and VIJAY K. PARMAR
patelhary@rediffmail.com
Department of Quality Assurance, L. M. College of
Pharmacy, Navrangpura, Ahmedaba-380 009, India
Accepted May 7, 2007
The binary system of etoricoxib with β-cyclodextrin
(β-CD) was prepared by the kneading method. Drug-cyclodextrin
interactions in solution were investigated by the phase solubility analysis.
Differential scanning calorimetry, infrared
spectroscopy, powder X-ray diffractometry and
microscopic study were used to characterize the solid state of all binary
systems, whereas their dissolution properties were evaluated according to the
USP XXIII paddle method. The results indicate partial interaction of the drug
with β-CD in the physical mixture and complete interaction in the kneaded
complex. The dissolution of etoricoxib was notably
increased as compared to pure drug as well as its physical mixture. The complex
showed more than 75% drug released in 30 min.
Keywords: etoricoxib, cyclodextrin, complexation,
kneading method