Acta Pharm. 56
(2006) 379-397
Original research paper
Quality assessment of the procedure for
determination of heavy metals on reactive carriers
JADRANKA
VUKOVIĆ*, VLADIMIR GRDINIĆ, RENATA JURIŠIĆ GRUBEŠIĆ and OGNJEN ŽUPANIĆ
jadranka@pharma.hr
Faculty of Pharmacy and Biochemistry,
Accepted
Quality control and validity check of the solid-phase spectrophotometric procedure (Me-SPS) for determination of
heavy metals important in pharmaceutical practice: zinc (Zn-SPS), lead (Pb-SPS), and cobalt (Co-SPS) were performed using a very
simple and informative prevalidation concept. Further,
metrological characteristics of the Me-SPS procedure together with the diagnosis
of particular prevalidation steps were evaluated. Favourable prevalidation
characteristics, i.e., ideal
analytical function, homogeneity of data material, low limit of quantitation, and acceptable accuracy verified the quality
of the Me-SPS procedure and pointed to the limitations of some investigated
systems.
Keywords: analytical procedure quality control, prevalidation
strategy, heavy metals, solid-phase spectrophotometry