Acta Pharm. 59 (2009) 383-393
Original research paper
Formulation
and evaluation of monolithic matrix polymer films for transdermal delivery of
nitrendipine
ASHU MITTAL *1,
UDAI VIR SINGH SARA 2 and ASGAR ALI3
mittalashu@yahoo.com
1ITS-Paramedical (Pharmacy) College, Ghaziabad, India
2D. J. College of Pharmacy, Ghaziabad, India
3Deparment of Pharmaceutics, Faculty of Pharmacy, Hamdard University,
New Delhi, India
Accepted July 27, 2009
The objective of the present work
was to develop a suitable transdermal drug delivery system for nitrendipine. Polymeric
films of nitrendipine were prepared by the film casting technique (glass ring)
on mercury substrate. They were evaluated for physicochemical parameters, in vitro release and ex vivo permeation (heat separated human
epidermis). Release of the drug from the films followed anomalous transport
(0.5 < n < 1).
Polymeric combination containing Eudragit RL 100:PVP K 30 in 4:6 ratio showed the best results. Maximum drug release and skin permeability coefficient in 48 h were 85.8 % and 0.0142 cm h-1, respectively, in formulation C3 (Eudragit RL 100: Plasdone S 630; 4:6) and 88.0 % and 0.0155 cm h-1, respectively, in formulation D3 (Eudragit RL 100: PVP K 30; 4:6). FTIR and TLC studies indicated no drug and polymer interaction.
Keywords: nitrendipine,
polymeric film, transdermal drug delivery, Eudragit RL 100, Plasdone S 630, PVP
K 30
1ITS-Paramedical (Pharmacy) College;
2 D. J. College of Pharmacy,
Ghaziabad,
3 Deparment of Pharmaceutics, Faculty
of Pharmacy,