Acta Pharm. 57 (2007) 395-411

full paper

Original research paper

Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives as anti-inflammatory, analgesic and ulcerogenic activity

ABDEL-RAHMAN. B. A. EL-GAZZAR*, HODA A. R. HUSSEIN and HEND N. HAFEZ

profelgazzar@yahoo.com

Photochemistry Department (Heterocyclic Unit), National Research Center, Dokki, Giza, Egypt

Accepted September 19, 2007

5-Methyl-6-phenyl-2-thioxothieno[2,3-d]pyrimidone derivative (2) reacted with hydrazonoyl chloride derivatives to afford triazolothienopyrimidones 4a-f. Also, acetone-1-(2-amino-5-isopropyl-thiophene-3-carbonitrile) (3) reacted with functional and bifunctional groups to yield the corresponding compounds 5-11. The new products showed anti-inflammatory, analgesic, and ulcerogenic activities comparable to that of indomethacin and acetylsalicylic acid, respectively.

Keywords: triazolothienopyrimidine, thienopyrimidines, thieno[2,3-d][1,3]thiazine, thieno-pyridines, analgesic, anti-inflammatory, ulcerogenic activity