Acta Pharm. 55 (2005) 401-408

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Original research paper  
 

Antimicrobial activity of some hydroxamic acids

STJEPAN PEPELJNJAK,1* BRANKA ZORC2 and IVAN BUTULA2

spep33@yahoo.com

1Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
2 Department of Medicinal Chemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Received January 20, 2005      Accepted June 4, 2005

Several hydroxamic acids, viz., N-benzyl-N'-hydroxysuccinamide (BHS) (1), poly[alpha,beta-(N-hydroxy)-DL-aspartamide] (PHA) (2), poly[alpha,beta-(N-hydroxy-N-methyl-DL-aspartamide)] (PMHA) (3) and poly [alpha,beta-(N-hydroxy)-DL-aspartamide]/poly[alpha,beta-(N-2-hydroxyethyl)-DL-aspartamide] (PHA-PHEA 1:1) (4) were prepared and screened for their antimicrobial activity. Ten Gram-positive and 7 Gram-negative species of bacteria, 5 Candida species, 4 dermatophytes species and 3 mould species were used in tests. Compound 1 showed no antimicrobial activity on any of the tested microorganisms. Other compounds (2-4) showed a narrow spectrum of antibacterial activity, but no antifungal activity.


Keywords: hydroxamic acid, polyhydroxamic acid, antimicrobial activity