Acta Pharm. 58 (2008) 43-59

full paper

Original research paper

New synthesized steroidal derivatives using 3b-hydroxyandrosten-17-one as starting material

NEHAD A. ABD EL-LATIF, MOHAMED M. ABDULLA and ABD EL-GALIL E. AMR

aamr1963@yahoo.com

Natural Compounds Department, National Research Center, Cairo, Dokki, Egypt

Research Units, Hi-Care Pharmaceutical Co., Cairo, Egypt

Applied Organic Chemistry Department, National Research Center, Cairo, Dokki, Egypt

Accepted February 5, 2008

In this study, we synthesized some new substituted steroidal derivatives using 3b-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives 1-11 were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (LD₅₀) of synthesized compounds are reported.

Keywords: dehydroepiandrosterone, steroidal derivatives, androgenic-anabolic agents