Acta Pharm. 62 (2012) 433-472

 

full paper

Review

 

Solid lipid based nanocarriers: An overview

CHANDRAKANTSING PARDESHI, PRAVIN RAJPUT, VEENA BELGAMWAR, AVINASH TEKADE, GANESH PATIL, KAPIL CHAUDHARY and ABHIJEET SONJE

chandrakantpardeshi11@gmail.com ; cvpardeshi@rcpatelpharmacy.co.in

1 R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, India

2 Rajarshi Shahu College of Pharmacy and Research, Pune-411033, India

3 H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur-425 405, India

4 Formulation Research and Development Department, Marksans Pharma. Ltd., Verna Industrial Estate, Verna-403722, India

5 Baxil Pharma. Pvt. Ltd., Nainital Highway, Shyampur, Haridwar-249408 India

Accepted September 12, 2012

 

In the era of nanoparticulate controlled and site specific drug delivery systems, use of solid lipids to produce first generation lipid nanoparticles, solid lipid nanoparticles (SLN), became a revolutionary approach in the early nineties. The present review is designed to provide an insight into how SLN are finding a niche as promising nanovectors and forms a sound basis to troubleshoot the existing problems associated with traditional systems. Herein, authors had tried to highlight the frontline aspects prominent to SLN. An updated list of lipids, advanced forms of SLN, methods of preparation, characterization parameters, and various routes of administration of SLN are explored in-depth. Stability, toxicity, stealthing, targeting efficiency and other prospectives of SLN are also discussed in detail. The present discussion embodies the potential of SLN, now being looked up by various research groups around the world for their utility in the core areas of pharmaceutical sciences, thereby urging pharmaceutical industries to foster their scale-up.

 

Keywords: colloidal drug carrier, solid lipid nanoparticles (SLN), stability, targeting efficiency, cytotoxicity, stealthing of SLN