Acta Pharm. 69 (2019) 443-449
Short communication
Haemostatic activity of
butanolic extracts of Lamium album and Lamium purpureum aerial
parts
CORINA BUBUEANU, RASIT IUKSEL and MINERVA PANTELI
corina.bubueanu@yahoo.com
1 Department of Pharmaceutical Biotechnology, National Institute for
Chemical-Pharmaceutical R&D (ICCF-Bucharest), Bucharest, Romania
2
Department of
Pharmacology, National Institute for Chemical-Pharmaceutical R&D
(ICCF-Bucharest), Bucharest, Romania
Accepted December 28, 2018
Published online January 21, 2019
Lamium album and Lamium
purpureum are species belonging to the genus Lamium.
Aerial parts of the two species and roots of Lamium
album have applications in human and veterinary traditional medicine.
Haemostatic properties of butanolic extracts of Lamium species were investigated by two experimental
models in Wistar rats: haemostatic test by tail
bleeding time determination and acenocoumarol-carrageenan
test. Results of the haemostatic test by tail bleeding determination demonstrated
haemostatic activity of both extracts. In the acenocoumarol-carrageenan test, only the Lamium
album extract showed haemostatic activity, comparable to that of vitamin K.
Based on the qualitative chemical data on iridoid
glycosides (HPTLC), 8-acetylshanzhiside methyl ester might
be assumed to be responsible for haemostatic activity. Based on the acute
toxicity test, none of the extracts showed toxicity.
Keywords: Lamium album, Lamium purpureum, aerial parts, butanolic extract,
haemostatic activity, toxicity