Acta Pharm. 56
(2006) 451-461
Original research paper
Evaluation
of a drug with wax-like properties as a melt binder
RAVINDRA
S. DHUMAL, SHAMKANT L. SHIMPI, BHASKAR CHAUHAN, KAKASAHIB R. MAHADIK and ANANT
PARADKAR*
anant_paradkar@yahoo.com
Department of
Pharmaceutics, Bharati Vidyapeeth
Deemed University,
The study investigates ibuprofen with wax-like properties as a multifunctional
agent (as an active component and as a melt binder). Binding efficiency was
compared with granules prepared by wet granulation using polyvinylpyrollidone
(PVP K-30) as a binder for micromeritic, physical and
mechanical properties such as angle of repose, particle size distribution Carr’s
index, Hausner’s ratio, crushing strength, percentage
fines, Heckel plot study and tensile strength. To
check the binder distribution during melt granulation, content uniformity was
determined. To check changes in the physical state of ibuprofen, XRPD, DSC and
FTIR studies were carried out. The present study underlines the fact that
ibuprofen may be adopted as a binder in ibuprofen formulations using the melt
granulation technique.
Keywords: ibuprofen,
binder, melt granulation