Acta Pharm. 65 (2015) 453-462
Original research paper
Preparation and investigation of mefenamic
acid-polyethylene glycol-sucrose ester solid dispersions
IBOLYA FÜLÖP, ÁRPÁD GYÉRESI, LÓRÁND KISS, MÁRIA A. DELI, MIRCEA DUMITRU CROITORU, PIROSKA SZABÓ-RÉVÉSZ and ZOLTÁN
AIGNER
croituru.mircea@umftgm.ro
1 University of Medicine and
Pharmacy, Tîrgu Mureş,
Faculty of Pharmacy, Department of Toxicology and Biopharmacy,
540139, Tîrgu Mureş,
Romania
2 University of Medicine and
Pharmacy, Tîrgu Mureş,
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 540139, Tîrgu Mureş, Romania
3 Institute of Biophysics, Biological
Research Centre,
4 University of
Accepted July 14, 2015
Mefenamic acid (MA) is a widely used non-steroidal anti-inflammatory (NSAID) drug. The adverse effects typical of NSAIDs are also present in the case of MA, partly due to its low water solubility. The aim of this study was to increase the water solubility of MA in order to influence its absorption and bioavailability. Solid dispersions of MA were prepared by the melting method using polyethylene glycol 6000 and different types (laurate, D-1216; palmitate, P-1670; stearate, S-1670) and amounts of sucrose esters as carriers. The X-ray diffraction results show that MA crystals were not present in the products. Dissolution tests carried out in artificial intestinal juice showed that the product containing 10 % D-1216 increased water solubility about 3 times. The apparent permeability coefficient of MA across human Caco-2 intestinal epithelial cell layers was high and, despite the difference in solubility, there was no further increase in drug penetration in the presence of the applied additives.
Keywords: mefenamic acid, sucrose esters, PEG 6000, solid dispersion, Caco-2 cells