Acta Pharm. 56 (2006) 463-471

full paper

Original research paper

Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives

DAVORKA BALLIAN KRZNAR¹, JELENA FILIPOVIĆ-GRČIĆ²
BRANKA ZORC^2* and MARIJANA ZOVKO²

bzbz@pharma.hr

¹ PLIVA – Research and Development, 10000 Zagreb, Croatia

² Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia

Accepted September 11, 2006

A series of mucoadhesive disks with celecoxib as a model drug of very low aqueous solubility were prepared and characterized. Two polymers of polyaspartamide type, poly[a,b-(N-2-hydroxyethyl-DL-aspartamide)] (PHEA, 1) and its thiolated analogue poly[α,β-(N-2-hydroxyethyl-DL-aspartamide)]-poly[α,β-(N-2-thioethyl-DL-aspartamide)] copolymer (PHTA, 2a,b), and two commercially available polymers Carbopol 934P and hydroxypropylmethyl cellulose 4000 were used as excipients. Disks containing a mixture of equivalent amounts of thiomer 2b and Carbopol 934P as an excipient exhibited the highest dissolution rate.

Keywords: celecoxib, disks, polyaspartamide, thiomer