Acta Pharm. 59 (2009) 463-472
Short communication
Chemical
composition of endemic Centaurea
austro-anatolica and studies of its the antimicrobial activity
against multi-resistant bacteria
AYSEL UGUR, NURDAN SARAC, OZGUR CEYLAN and M. EMIN
DURU
1 Department
of Biology, Faculty of Arts and Sciences, Mugla University, 48121
Kotekli-Mugla, Turkey
2 Medical Laboratory Program, Vocational School of
Health Services, Mugla University, 48700 Marmaris-Mugla, Turkey
3 Department of Nursing, Health College, Usak
University, 64100 Usak, Turkey
4 Department of Chemistry, Faculty of Arts and
Sciences, Mugla University, 48121 Kotekli-Mugla, Turkey
Accepted September 15, 2009
Hexane, chloroform, ethyl acetate and ethanolic extracts of the aerial parts of C. austro-anatolica Hub.-Mor. (Asteraceae) were evaluated against microorganisms, including multi-resistant bacteria, using a paper disc diffusion method. The chloroform extract exhibited significant antibacterial activity toward all bacteria tested. The chemical composition of the chloroform extract was determined by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The major compounds of the extract were caryophyllene oxide (21.32 %), spathulenol (10.86 %), n-tricosanol (9.58 %) and geranyl isovalerate (8.71 %).
Keywords: Centaurea austro-anatolica (Asteraceae), chemical composition,
antimicrobial activity