Acta Pharm. 67 (2017) 463-478
Original research paper
Spectrophotometric method for
simultaneous determination of valsartan and
substances from the group of statins in binary
mixtures
MARIUSZ STOLARCZYK, ANNA APOLA, ANNA MAŚLANKA, ANNA KWIECIEŃ and WŁODZIMIERZ
OPOKA
Department of Inorganic and Analytical Chemistry, Jagiellonian University Medical College, Faculty of
Pharmacy, 30-688 Kraków, Poland
Accepted June 6, 2017
Published online August 25,
2017
Applicability of derivative spectrophotometry
for the determination of valsartan in the presence of
a substance from the group of statins was checked.
The obtained results indicate that the proposed method may be effective by
using appropriate derivatives: for valsartan and fluvastatin – D1, D2 and D3, for valsartan
and pravastatin – D1 and D3, for valsartan
and atorvastatin – D2 and D3. The method was
characterized by high sensitivity and accuracy. Linearity was maintained in the
following ranges: 9.28–32.48 mg mL–1
for valsartan, 8.16–28.56 mg mL–1
for fluvastatin, 14.40–39.90 mg mL–1 for atorvastatin and 9.60–48.00 mg mL–1 for pravastatin. Determination coefficients were in the
range of 0.989–0.999 depending on the analyte and the
order of derivative. The precision of the method was high with RSD from 0.1 to
2.5 % and recovery of individual components was within the range of 100 ± 5 %. The developed method was successfully applied to the
determination of valsartan combined with fluvastatin, atorvastatin and pravastatin in laboratory prepared mixtures and in
pharmaceutical preparations.
Keywords: valsartan, atorvastatin, fluvastatin, pravastatin, derivative spectrophotometry