Acta Pharm. 57 (2007) 47-60

full paper

Original research paper

 

Physicochemical characterization and in vitro dissolution behaviour of celecoxib-b-cyclodextrin inclusion complexes

 

VIVEK RANJAN SINHA1*, R. ANITHA1, SOMA GHOSH2, AMITA1, RACHANA KUMRIA1, JAYANT RAJARAM BHINGE1, MANOJ KUMAR1

vr_sinha@yahoo.com

1 University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

2 Department of Chemistry, Panjab University, Chandigarh, India

Accepted October 6, 2006

 

In this study, attempts were made to investigate the effects of b-cyclodextrin (b-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion complexes were prepared by the kneading method and characterized by SEM, NMR, IR, DSC, and X-ray powder diffraction. Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.

 

Keywords: celecoxib, b-cyclodextrin, inclusion complex, dissolution profile