Acta Pharm. 59 (2009) 473-482
Short communication
An improved procedure for synthesis of some new
1,3-diaryl-2-propen-1-ones using PEG-400 as a recyclable solvent and their
antimicrobial evaluation
BHASKAR
S. DAWANE*, SHANKARAIAH G. KONDA, BASEER M. SHAIKH and RAGHUNATH B.
BHOSALE
bhaskardawane@rediffmail.com,
kondasg@rediffmail.com
Organic
Research Laboratory, Department of Chemistry, Yeshwant Mahavidyalaya,
Nanded-431602 (M.S) India
Accepted August 26, 2009
A simple and convenient route is described for the synthesis of novel hetero 1,3-diaryl-2-propen-1-ones (chalcones) by using recyclable poly PEG-400 as an alternative reaction solvent. The reaction is clean with excellent yield, shorter reaction time and reduces the use of volatile organic compounds (VOCs). All the synthesized compounds were evaluated for their antimicrobial activities against several pathogenic representatives.
Keywords: 1,3-diaryl-2-propen-1-ones, PEG-400, antimicrobial activity