Acta Pharm. 60 (2010) 479-491
Original research paper
Potential antimicrobial
activity of some synthesized glucopyranosyl-pyrimidine carbonitrile and fused
pyrimidine systems
Hayam H. SAYED,
Hebat-Allah S. Abbas, Eman M. H. MORSI, Abd El-Galil E. AMR and Nayera
A. M. ABDELWAHAD
1 Photochemistry
Department, National Research Centre, 12622 Dokki, Cairo, Egypt
2 Department
of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh
11451, Saudi Arabia
3 Chemistry of Natural and Microbial Product
Department, National Research Centre, 12622 Dokki, Cairo, Egypt
Accepted October 4, 2010
3-Amino-5-(4-chlorophenylamino)-4-cyanofuran-2-carboxamide
(2) was used as the key molecule for preparation of various furo-
pyrimidines 3-9 and formation of spiro-cycloalkane furopyrimidines
10, 11. Also, poly fused heterocyclic compounds 13-17
were prepared from compound 2. The synthesized compounds were
screened for their antimicrobial activity.
Keywords: pyrimidine, glucopyranosyl-pyrimidine, oxazine,
antimicrobial activity