Acta Pharm. 67 (2017) 479-494
Original research paper
Gastroprotective effects of the isopropanol extract of Artemisia
princeps and its gastroretentive
floating tablets on gastric mucosal injury
Joo-Il Kim, Sang-Wook Park, Jhong-Jae
Lim, Se-Il Sohn, Ji-Sun
Shin, Sang Cheol Park, Young Pyo Jang, EUN KYOUNG CHUNG, Hong-Woo Lee and Kyung-Tae Lee
1 Department of Pharmaceutical Biochemistry, College
of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea
2Central Research
Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu,
Seoul, Republic of Korea
3 Interdisciplinary Program in Agricultural Biotechnology,
College of Agriculture and Life Sciences, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul,
08826, Korea
4Department of Life
and Nanopharmaceutical Science, College of Pharmacy,
Kyung Hee University, 26,
Kyungheedae-ro, Dongdaemun-gu,
Seoul, 02447, Korea
5 Department
of Oriental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro,
Dongdaemun-gu, Seoul, 02447, Korea
6 Department
of Pharmacy, College of Pharmacy, Kyung Hee
University, 26, Kyungheedae-ro, Dongdaemun-gu,
Seoul, 02447, Korea
Accepted September 28, 2017
Published online October 30,
2017
In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin-treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAP-FR was retained for >2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer.
Keywords: Artemisia princeps
Pamp., antiulcer, eupatilin, floating drug delivery system, X-ray photographs