Acta Pharm. 50 (2000) 49-55

Original scientific paper  
 

The decrease of Na+,K+-ATPase activity in the renal cortex and medulla induced by enalapril

MIRELA MATASIC-ROSSINI  and   ITA SAMARZIJA 

Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Received September 13, 1999      Accepted January 21, 2000

In this study the influence of enalapril (1 mg kg-1 b. m.), on the Na+,K+-ATPase activity in samples of renal cortex and medulla was investigated. The results showed that after one-day treatment the Na+,K+ -ATPase activity had already decreased: in cortical samples the reduction was 16.4 5.7%, whereas in medullar ones it was 10.6 4.9% (n = 10) if compared to the controls. A seven-day treatment with enalapril induced no additional effects in the cortical samples, whereas the medullar decrement was as high as 26.9% in comparison to the controls. A fourteen-day treatment induced a decrease of Na+,K+-ATPase activity in the cortical and medullar samples of 48.6% and 46.7%, respectively, in comparison to the control group.


Keywords: Na+,K+-ATPase, enalapril, kidney, cortex, medulla