Acta Pharm. 63 (2013) 531-543


full paper

Original research paper


Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil


1 The Ministry of Health of Turkey, Turkish Medicines and Medical Devices Agency, Söğütözü Mahallesi, 2176, 06520 Çankaya-Ankara, Turkey

2 Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ankara, 06100 Tandoğan-Ankara, Turkey

3 Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, 34116 Beyazıt-Istanbul, Turkey

Accepted September 25, 2013


Prevention of skin aging and its treatment is an emerging field for development of new formulations in cosmetics. Accordingly, plant extracts with antioxidant properties are beneficial cosmetic ingredients for this purpose. This study was aimed at developing a stable and easily manufactured emulgel including green tea extract and rose oil that is effective on the barrier function and hydration of skin. An emulgel formulation containing 20 % green tea extract and 5 % rose oil was designed as a result of pre-formulation studies. Physicochemical characterization, in vitro stability studies, in vivo water content of the stratum corneum and transepidermal water loss studies were carried out afterwards. In vivo studies on ten female subjects were evaluated by using non-invasive skin bioengineering techniques. Finally, a cosmetically acceptable, stable and effective emulgel formulation for skin barrier function with good hydrating properties was obtained for skin hydration, protection and anti-aging purposes.


Keywords: green tea extract, rose oil, emulgel, skin water content, transepidermal water loss, biophysical measurements