Acta Pharm. 69 (2019) 533-540


full paper



Actualities in the phytochemical research on selected terpenes


1 University of Split, Faculty of Chemistry and Technology, HR-21000 Split, Croatia

2 University of Zagreb Faculty of Pharmacy and Biochemistry, HR-10000 Zagreb, Croatia

Accepted February 14, 2019

Published online March 22, 2019


A short review of our recent research on the essential oil phytochemical composition of Petasites albus (L.) Gaertn. and Petasites hybridus (L.) G. Gaertn., B. Mey. & Scherb. (Asteraceae) as well as on the oils of Globularia cordifolia L., Globularia meridionalis (Podp.) O. Schwarz and Globularia punctata Lapeyr. (Plantaginaceae) is presented. All essential oils contained a variety of oxygenated sesquiterpenes among their major constituents, including a bakkane type sesquiterpene fukinanolid (bakkenolide A). The paper is focused on: a) a short overview of the abundance of major terpenes in the essential oils of Petasites and Globularia species from Croatia; b) possible biosynthetic pathways of major identified sesquiterpenes; and c) biological activities (literature data) of major sesquiterpenes from Petasites and Globularia species.


Keywords: Petasites species, Globularia species, oxygenated sesquiterpenes, bisabola-2,10-diene-1-one, fukinanolid (bakkenolide A), dehydrofukinone