Acta Pharm. 67 (2017) 569-578
Short communication
The
influence of the plasma on physical properties of the ointments with quercetin
BEATA
SZULC-MUSIOŁ, BARBARA DOLIŃSKA, JUSTYNA KOŁODZIEJSKA and FLORIAN RYSZKA
bszulc@sum.edu.pl
1 Department
of Applied Pharmacy, School of Pharmacy and the Division of Laboratory
Medicine, Medical University of Silesia, Poland
2 Department
of Applied Pharmacy, Medical University of Łódź,
Poland
3 Pharmaceutical
Research and Production Plant "Biochefa", Sosnowiec, Poland
Accepted September 25, 2017
Published online November
29, 2017
Effects of two independent variables – the content of quercetin (0 or 1 or 1.5 or 5 %) and the content of plasma (0 or 2 or 4 or 6 %) – on the organoleptic properties and rheological parameters of model formulations prepared on an amphiphilic base were estimated. The consistency of all ointments was uniform, and the content of quercetin and plasma lay within the predefined range. Tested ointments are non-Newtonian systems. The content of quercetin and plasma was found to have a significant effect on the rheological properties of the ointments. An increase in the content of plasma in ointments was accompanied by a significant increase in their hardness, viscosity and shear stress and a reduction of their spreadability. The best rheological properties were shown by formulation F-3, containing 1.5 % of quercetin and 2 % of plasma.
Keywords: quercetin, plasma, ointment, rheological property