Acta Pharm. 53 (2003) 57-64

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Short communication  
 

Formulation of fast release glibenclamide liquid and semi-solid matrix filled capsules

SALY GALAL, MAGDA EL- MASSIK, * OSSAMA ABDALLAH   and NABILA DAABIS

magdaelmassik@yahoo.com

Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Egypt
Received June 3, 2002      Accepted January 26, 2003

The ability of liquid and semi-solid matrix (SSM) filling capsule technology to improve the dissolution rate of glibenclamide (GBD) was investigated. Semi-quantitative estimation of GBD solubility in various vehicles was carried out. Tetraglycol was found to be the most efficient solubilizer. GBD was formulated in different concentrations as solutions in tetraglycol or tetraglycol/ PEG 6000 blend and as suspensions in SSM composed of Gelucire 44/14 as a base. Dissolution rate studies revealed that the release profiles of GBD from capsule formulations containing the drug in concentrations up to 3.5% (m/m) were comparable.


Keywords: liquid matrix, semi-solid matrix, capsules, glibenclamide, dissolution