Acta Pharm. 69 (2019) 661-672

full paper

Original research paper

Antiproliferative evaluation of various aminoquinoline derivatives

BRANKA ZORC, ZRINKA RAJIĆ and IVANA PERKOVIĆ

bzorc@pharma.hr

University of Zagreb Faculty of Pharmacy, 10 000 Zagreb, Croatia

Accepted June 24, 2019

Published online July 31, 2019

Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adenocarcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC₅₀ values in low micromolar range against all tested cancer cell lines.

Keywords: primaquine, chloroquine, mefloquine, fumardiamide, antiproliferative activity