Acta Pharm. 59 (2009) 67-73
Potential prophylactic role of aminoguanidine in diabetic retinopathy and nephropathy in experimental animals
AMANY HASSAN M. EL SHAZLY, ATEF MOHAMED MAHMOUD and NEVINE SALAH DARWISH
1Department of Pharmacology, 2Biochemistry and 3Histology Research Institute of Ophthalmology, Giza, Egypt
Accepted February 9, 2009
This study sought to determine the potential prophylactic and antioxidant effects of aminoguanidine in experimentally induced diabetes. Four groups of Wistar rats, each composed of ten rats, were used. Two groups served as control. In group 3, diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg kg-1). In group 4, diabetes was induced and treated with aminoguanidine 100 mg kg-1 daily orally for 3 months. Levels of serum glucose, glutathione peroxidase, glutathione reductase and erythrocytes catalase were analyzed on day 90 of the experiment. Retinal and kidney specimens were examined histopathologically after sacrifice of the animals. A significant antioxidant effect of aminoguanidine and its prophylactic role in diabetic retinopathy and nephropathy were observed in experimental animals.
Keywords: aminoguanidine, diabetic retinopathy, nephropathy, nitric oxide, glycated end product, antioxidants