Acta Pharm. 69 (2019) 695-704
Short communication
Efficacy and safety of
local lysozyme treatment in patients with oral mucositis after chemotherapy and
radiotherapy
DZENANA EMINAGIĆ, AIDA LOKVANČIĆ, BERISA HASANBEGOVIĆ, ALMA MEKIĆ-ABAZOVIĆ,
ASMIR AVDIČEVIĆ, INGA MARIJANOVIĆ, SLOBODAN M. JANKOVIĆ and BELMA KAPO
1 Clinical Center University of
Sarajevo, Bosnia and Herzegovina
2 Bosnalijek JSC, Sarajevo, Bosnia
and Herzegovina
3 Zenica Cantonal Hospital, Bosnia
and Herzegovina
4 University Clinical Center Tuzla,
Bosnia and Herzegovina
5 University Hospital Mostar, Bosnia
and Herzegovina
6 University of Kragujevac, Faculty
of Medical Sciences, Serbia
Accepted July 2, 2019
Published online September 10, 2019
This observational clinical study was composed of two substudies: a non-comparative one (n = 166), testing only lysozyme-based compounds (LBCs), and a comparative substudy (n = 275), testing both LBCs and bicarbonate-based local compounds (BBCs) on the healing of oral mucositis during radio- or chemotherapy. The density of ulcerations has decreased significantly after the treatment with lysozyme in both substudies. The density of ulcerations in the radiotherapy group was lower in patients treated with LBCs compared to patients treated with BBCs (p < 0.001). In the chemotherapy group, reduction of ulceration density was similar with both LBCs and BBCs. The LBCs reduced pain intensity during the intake of solid food and speech more than BBCs in both patient cohorts (p < 0.05). In the radiotherapy cohort, pain intensity when consuming liquid foods was reduced more with LBCs than with BBCs (p < 0.05). No adverse events were recorded. This study demonstrates the advantages of treating oral mucositis during radiotherapy or chemotherapy with LBCs.
Keywords: oral mucositis, treatment efficacy, radiotherapy, chemotherapy,
topical, lysozyme