Acta Pharm. 49 (1999) 71-77

Original scientific paper  
 

Treatment of carbamate and organophosphate intoxication with new oximes

BOZICA RADIC,*1  ANA LUCIC,1  MAJA PERAJICA,1 
and   VLASTA BRADAMANTE2

1Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia 
2Faculty of Medicine, University of Zagreb, Salata 11, 10000 Zagreb, Croatia 
Received  January 28,1998      Accepted  March 29, 1998

Antidotal effect of bis-imidazolium oxime BDB-122 and quinuclidinium- imidazolium oxime BM-1 was tested in intoxication with some carbamates and organophosphorus compounds (OPs). Their effects were tested in vitro on human erythrocytes acetylcholinesterase (AChE) and in vivo on mice. Each oxime applied together with atropine had good therapeutic effect in intoxication with carbamates (propoxur, carbaryl, RO2-0683) and OPs (dichlorvos and soman). Oxime BDB-122 with atropine protected mice against 16.0 LD50 of propoxur, 2.0 LD50 of carbaryl, 8.0 LD50 of RO2-0683, 22.4 LD50 of dichlorvos, and 2.0 LD50 of soman, whereas oxime BM-1 with atropine yielded a 100% survival of mice intoxicated with 16.0 LD50 of propoxur, 2.5 LD50 of carbaryl, 20.0 LD50 of RO2-0683, 11.5 LD50 of dichlorvos, and 4.0 LD50 of soman. Good therapeutic effect of tested oximes in intoxication with carbamates is especially interesting because, actually, the drug of choice is atropine only.

Keywords: carbamates, organophosphorus compounds, oximes therapy, acetylcholinesterase