Acta Pharm. 59 (2009) 73-88

 

full paper

Original research paper

 

Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of
1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles

ADEL H. MANDOUR, ESLAM R. EL-SAWY, KAMEL H. SHAKER and MOHAMED A. MUSTAFA

ahmandour_z @ yahoo.com

1 Chemistry Department of Natural Compounds, National Research Centre, Gizza, Egypt

2 Organic Chemistry NWII,1/2, University of Bayreuth, Bayreuth, Germany

3 Research Unit, Egypt Pharmacist Co., Cairo, Egypt

Accepted January 25, 2010

 

A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles 4a-j, 5a-j and 6a-j has been synthesized and tested for their anti-inflammatory and anticonvulsant activities. Formation of the pyrazoloindole derivatives was achieved by treating arylhydrazones of N-alkyl indole-3-carboxaldehydes 1a-j, 2a-j and 3a-j with ten times their mass of polyphosphoric acid as a condensing agent. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anticonvulsant activities compared to indomethacin, flufenamic acid and diazepam as positive controls. Detailed synthesis, spectroscopic and toxicity data are reported.

 

Keywords: indole-3-carboxaldehyde, anti-inflammatory activity, anticonvulsant activity, analgesic activity