Acta Pharm. 59 (2009) 89-97

full paper

Original research paper

Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine

SURESH BANDARI, CHANDRA MOHAN EAGA, ASHOK THADISHETTY and MADHUSUDAN RAO YAMSANI

yamsani123@gmail.com

Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P.), India

Accepted October 24, 2009

A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L^-1 HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.

Keywords: biphasic release, gastroretention, multiple matrix tablet, release kinetics