Acta Pharm. 53 (2003) 91-100

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Original research paper  
 

Hepatoprotection by 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one against experimentally induced liver injury in rats

BRAJENDRA KUMAR TRIPATHI,1 SAVITA SRIVASTAVA,1 RAVI RASTOGI,1 DEEPAK RAINA,1 
VISHNU JI RAM2and ARVIND KUMAR SRIVASTAVA1*

drarv1955@yahoo.com

1Division of Biochemistry, Central Drug Research Institute, Lucknow-226001, India
2Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow-226001, India

Received September 12, 2002      Accepted April 22, 2003

Hepatoprotective activity of 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one, an isostere of dimethyl ricinine, was evaluated in adult male albino rats intoxicated with carbon tetrachloride, paracetamol or thioacetamide, respectively. The test compound showed significant hepatoprotection at 6.0 mg kg-1 body mass daily dose, given to the rats for seven consecutive days. The carbon tetrachloride, paracetamol and thioacetamide were given respectively on days 3, 5, and 7, on day 6 and on day 6 post treatment with the test compound. The protective effect was evident in a batterry of serum and liver biochemical parameters related to hepatotoxicity.


Keywords: 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one, carbon tetrachloride, paracetamol, thioacetamide, hepatoprotection, hepatotoxicity