Acta Pharm. 65 (2015) 91-98
Compressibility of tableting materials and properties of tablets with glyceryl behenate
JITKA MUŽÍKOVÁ, SANDRA MUCHOVÁ, ALENA KOMERSOVÁ and VÁCLAV LOCHAŘ
1 Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic
2 Department of Physical Chemistry, University of Pardubice, Faculty of Chemical Technology, Pardubice, Czech Republic
Accepted October 14, 2014
The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl behenate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Release rate of the active ingredient, salicylic acid, from the tablets was also examined. In the case of microcrystalline cellulose, a higher concentration of glyceryl behenate increased the strength of tablets, while this did not occur in the case of spray-dried lactose. Increasing concentration of glyceryl behenate prolonged the release of salicylic acid; however, no statistically significant difference was found compared to the type of the dry binder used.
Keywords: lipophilic matrix tablet, glyceryl behenate, salicylic acid, energy profile of compression, tensile strength of tablets, dissolution profile