Acta Pharm. 62 (2012) 93-104
Original research paper
Design and evaluation of moxifloxacin
hydrochloride ocular inserts
PRAVIN K. PAWAR, RAJESH KATARA and DIPAK K.
MAJUMDAR
1 Chitkara College of Pharmacy, Chitkara University,
Chandigarh-Patiala National Highway, Rajpura, Rajpura-140401, Patiala, Punjab,
India
2 Department
of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research (formerly
College of Pharmacy), University of Delhi, Pushp Vihar, Sector III, New
Delhi-110017, India
Accepted December 16, 2011
The objective of the present investigation was to prepare and evaluate ocular inserts of moxifloxacin. An ocular insert was made from an aqueous dispersion of moxifloxacin, sodium alginate, polyvinyl alcohol, and dibutyl phthalate by the film casting method. The ocular insert (5.5 mm diameter) was cross-linked by CaCl2 and was coated with Eudragit S-100, RL-100, RS-100, E-100 or Eudragit L-100. The in vitro drug drainage/permeation studies were carried out using an all-glass modified Franz diffusion cell. The drug concentration and mucoadhesion time of the ocular insert were found satisfactory. Cross-linking and coating with polymers extended the drainage from inserts. The cross-linked ocular insert coated with Eudragit RL-100 showed maximum drug permeation compared to other formulations.
Keywords: moxifloxacin, ocular insert, goat
cornea