Acta Pharm. 51 (2001) 95-106
In search of therapeutically useful muramyl dipeptide related analogues, a series of phthalimido desmuramyl dipeptides has been synthesized. Immunobiological properties of compounds were examined in an in vivo immunorestoration test. LK-413 and LK-423 were selected for further ex vivo immunological studies to investigate their ability to influence the IL-2 production and activation of macrophages. Jerne's plaque forming cells assay was performed to monitor the effect of B cell differentiation. Blast transformation of T cells stimulated with ConA was used to detect the influence on T lymphocytes. The immunossupressive or immunostimulating activity of the compounds tested can be interpreted as a result of attachment of different parts of the molecule to different immunocompetent cells that show their specific responses in a dose dependent manner.
Keywords: desmuramyl dipeptides, immunomodulation, immunorestoration, IL-2