Acta Pharm. 49 (1999) 99-105

Original scientific paper  
 

Dynamics of liver tissue zinc and copper during compensatory liver growth in mice

DIJANA BISIC, MARIJA SIMIN, DONATELLA VERBANAC, and CEDOMILA MILIN

Department of Chemistry and Biochemistry, Medical School, University of Rijeka, Rijeka, Croatia
Received  February 12, 1999      Accepted  May 28, 1999

In this work we followed the dynamics of zinc and copper concentration in liver tissue during compensatory liver growth (CLG) (24 and 48 h, 7 and 15 days) after partial hepatectomy (pHx) on Balb/c mice. Significant increase of zinc and copper levels in liver after 48 h in pHx and sham operated animals, indicates that these two elements are necessary during the CLG. The obtained results were supported by zinc and copper concentration in peripheral organs, kidney and muscle.

Keywords: zinc, copper, partial hepatectomy, compensatory liver growth