Acta Pharm. 57
(2007) 241-248
Short communication
Hepatoprotective effect of the ethyl
acetate extract of Teucrium polium L. against carbon tetrachloride-induced hepatic
injury in rats
TATJANA KADIFKOVA PANOVSKA1*, SVETLANA
KULEVANOVA2, ICKO GJORGOSKI3, MIRJANA BOGDANOVA4
and GORDANA PETRUSHEVSKA5
taka@ff.ukim.edu.mk
1Institute
of Toxicology, Faculty of Pharmacy, University “Ss. Cyril and Methodius”, 1000 Skopje, Republic of Macedonia
2Institute
of Pharmacognosy, Faculty of Pharmacy, University
“Ss. Cyril and Methodius”, 1000 Skopje, Republic of
Macedonia
3Institute
of Biology, Faculty of Natural Sciences and Mathematics, University “Ss. Cyril
and Methodius”, 1000 Skopje, Republic of Macedonia
4Institute
of Clinical Biochemistry, Clinical Center, 1000 Skopje, Republic of Macedonia
5Institute
of Pathology, Faculty of Medicine, University “Ss. Cyril and Methodius”, 1000 Skopje, Republic of Macedonia
Accepted March 5, 2007
Hepatoprotective
activity of the ethyl acetate extract of Teucrium polium
(L.) was investigated using rats with CCl4-induced liver damage.
Specific biochemical parameters (glutathione peroxidase,
superoxide dismutase,
reduced glutathione and total antioxidative status)
were estimated in blood and in liver homogenate. Lipid peroxidation
in CCl4-intoxicated rats was evidenced by a marked increment in the
levels of thiobarbituric acid reactive substances. Histopatological examinations of the liver were undertaken
to monitor the liver status. Silymarin was used as a
standard to compare the hepatoprotective activity of
the extract. Some biochemical parameters in groups treated with the Teucrium polium extract at a dose of 25 mg kg-1, showed
significantly different values than that of the CCl4-treated group.
The liver biopsy of all experimental rat groups treated with the Teucrium polium ethyl
acetate extract showed significant restoration of the normal histomorphological pattern of liver cells. The study
substantiates the potential hepatoprotective activity
of the ethyl acetate extract of Teucrium polium L.
Keywords: Teucrium
polium
(Lamiaceae), hepatoprotective
effect, carbon tetrachloride, sylimarin, glutathione