ACTA
PHARMACEUTICA
Acta Pharm. Vol. 59 No. 1 pp. 1-119 Zagreb,
March 2009
TABLE OF CONTENTS
ORIGINAL RESEARCH PAPERS
B.
Singh, S. Pahuja, R. Kapil and N. Ahuja
Formulation development of oral controlled release tablets of hydralazine: Optimization of drug release and bioadhesive characteristics . . . . . . . . . . . . . . . . . . .1
P. Kumar, S. Singh and B. Mishra
Development and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technology. . . . . . . . . . . . . . . . . . . . . . . .15
N.
Dessalew
Investigation of the structural requirement for inhibiting HIV integrase: QSAR study. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .31
A. R. Jalilian, N. Rostampour, P. Rowshanfarzad, K. Shafaii, M. Kamali-Dehghan, and M. Akhlaghi
Preclinical studies of [61Cu]ATSM as a PET radiopharmaceutical for fibrosarcoma imaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
M. P.
Patil and N. J. Gaikwad
Preparation and characterization of gliclazide-polyethylene glycol 4000 solid dispersions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
SHORT COMMUNICATIONS
A. H. M. El Shazly, A. M. Mahmoud and N. S.
Darwish
Potential prophylactic role of aminoguanidine in diabetic retinopathy and nephropathy in experimental animals. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .67
V.
Alagarsamy, D. Shankar, V. R. Solomon, R. V. Sheorey and P. Parthiban
Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents. . . . . . . . . . . . . . .75
G. Lodhi, H. K. Singh, K. K. Pant and Z. Hussain
Hepatoprotective
effects of Calotropis gigantea
extract against carbon tetrachloride induced liver injury in rats. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 89
V.
Alagarsamy, K. Kavitha, M. Rupeshkumar,
V. R. Solomon, J. Kumar, D. S. Kumar and H. K. Sharma
Synthesis and pharmacological investigation of novel 4-(3-ethylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as a new class of H1-antihistaminic agents. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
Z. Rajić, G. Kos, B. Zorc, P. P. Singh and S.
Singh
Macromolecular
prodrugs. XII. Primaquine conjugates: Synthesis and preliminary antimalarial
evaluation. . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . 107
BOOK REVIEWS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117